Had evidence of
chronic organ damage at autopsy
had chronic organ damage
previously noted in their clinical histories
(n=306; autopsy study)
Chronic organ damage driven by the downstream effects of HbS polymerization—hemolysis, anemia,
and vaso-occlusion—is responsible for the morbidity and mortality of most patients with SCD.
However, it can often go unrecognized.6,9
There is an ongoing need for improved management of patients with SCD and related end-organ damage. Inhibiting polymerization may provide a key therapeutic strategy to impact red blood cell sickling, which drives the broad cascade of SCD pathologies.10
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